DANE R. BOGGS, M.D.; EMIL FREI III, M.D.; CHARLES H. ZIERDT, M.S.
Fever, in the absence of demonstrable infection, occurs frequently in patients with malignant neoplastic disease. Its pathogenesis is obscure. Occult bacterial infection1, 2, 3 has not been excluded as a cause of such fever. While the availability of antibiotics has reduced morbidity and possibly prolonged survival in patients with malignant neoplastic disease, the decision as to whether they should be used in patients with fever without demonstrable infection remains a difficult and controversial one. Such fever frequently disappears with antibiotic therapy,1, 3 but this may be a function of the natural duration of the fever, rather than a therapeutic
BOGGS DR, FREI E, ZIERDT CH. FEVER IN MALIGNANT NEOPLASTIC DISEASE: A CONTROLLED STUDY OF TETRACYCLINE THERAPY*. Ann Intern Med. 1960;53:754–764. doi: https://doi.org/10.7326/0003-4819-53-4-754
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Published: Ann Intern Med. 1960;53(4):754-764.
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