PAUL HELLER, M.D., F.A.C.P.; HYMAN G. WEINSTEIN, M.S.; MICHAEL WEST, M.D.; HYMAN J. ZIMMERMAN, M.D., F.A.C.P.
Several published studies1, 2, 3, 4 have shown that patients with megaloblastic anemia have markedly elevated serum levels of lactic dehydrogenase. The sera of patients with sickle cell anemia were found to contain only slightly to moderately elevated levels of this enzyme. In most other forms of anemia the serum levels were within normal limits.2
The possibility was considered that these elevations of the serum or plasma lactic dehydrogenase in megaloblastic anemia might reflect an abnormality peculiar to the megaloblastic cell series, consisting of an abnormally high content of lactic dehydrogenase and increased activity of the anaerobic glycolytic cycle. This
HELLER P, WEINSTEIN HG, WEST M, et al. ENZYMES IN ANEMIA: A STUDY OF ABNORMALITIES OF SEVERAL ENZYMES OF CARBOHYDRATE METABOLISM IN THE PLASMA AND ERYTHOCYTES IN PATIENTS WITH ANEMIA, WITH PRELIMINARY OBSERVATIONS OF BONE MARROW ENZYMES*. Ann Intern Med. 1960;53:898–913. doi: https://doi.org/10.7326/0003-4819-53-5-898
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Published: Ann Intern Med. 1960;53(5):898-913.
Hematology/Oncology, Red Cell Disorders.
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