BALDO M. CARNECCHIA, M.D.; JOHN F. KURTZKE, M.D.
Cryptococcus neoformans (Torula histolytica) causes a subacute or chronic meningo-encephalitis which is uniformly fatal. The duration of illness may vary from about three weeks1 to almost 16 years2 after the onset of symptoms. The majority of patients succumb within six months of onset, and from 80 to 90% of patients are dead within the first year.3 The tendency toward remissions and exacerbations in this disorder has made difficult the evaluation of therapy. In the past, treatment of torular meningo-encephalitis has been ineffective. However, in 1957 Appelbaum and Shtokalko4 reported arrest of the disease for seven months in a patient given
CARNECCHIA BM, KURTZKE JF. FATAL TOXIC REACTION TO AMPHOTERICIN B IN CRYPTOCOCCAL MENINGO-ENCEPHALITIS1. Ann Intern Med. 1960;53:1027–1036. doi: 10.7326/0003-4819-53-5-1027
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Published: Ann Intern Med. 1960;53(5):1027-1036.
CNS Infections, Emergency Medicine, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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