JOHN B. VANDER, M.D.; HORTON A. JOHNSON, M.D.
The close relationship which seems to exist between lymphocytes and plasma cells has recently been the subject of much discussion.1, 2 The frequent occurrence of apparently identical serum protein abnormalities in patients with malignant lymphoma, lymphatic leukemia and multiple myeloma, as demonstrated by paper electrophoresis, has been felt to be of particular significance. The consensus seems to be that plasma cells probably represent transitional forms of lymphocytes, as had been suggested by the work of Sundberg3 and others,4 and that both are capable of synthesizing abnormal serum proteins.
Although serum proteins of the myeloma type have occasionally been reported in
VANDER JB, JOHNSON HA. CHRONIC LYMPHATIC LEUKEMIA AND MULTIPLE MYELOMA IN THE SAME PATIENT*. Ann Intern Med. 1960;53:1052–1059. doi: https://doi.org/10.7326/0003-4819-53-5-1052
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Published: Ann Intern Med. 1960;53(5):1052-1059.
Hematology/Oncology, Leukemia/Lymphoma, Multiple Myeloma.
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