LEONARD S. DREIFUS, M.D.; CRISTOBAL DUARTE, M.D.; RYUICHI KODAMA, M.D.; JOHN H. MOYER, M.D.
Thiazide diuretics have been used with rather favorable results in the presence of renal disease.1-4 Furthermore, several investigators1, 4-7 have reported a low incidence of toxicity with the use of these drugs in patients with normal as well as with diseased kidneys. On the other hand, patients with liver disease and ascites appeared to be less responsive to these agents. Chlorothiazide, given to patients with cirrhosis, was associated with a reduction in serum potassium and a concomitant increase in the blood pH. Beyer6 has demonstrated the effectiveness of chlorothiazide in the presence of both acidosis and alkalosis. Chlorothiazide will enhance
DREIFUS LS, DUARTE C, KODAMA R, MOYER JH. THE EFFECT OF THIAZIDE DIURETICS ON THE ABNORMAL KIDNEY12. Ann Intern Med. 1960;53:1170–1179. doi: 10.7326/0003-4819-53-6-1170
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Published: Ann Intern Med. 1960;53(6):1170-1179.
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