JOHN C. HOAK, M.D.; WILLIAM E. CONNOR, M.D.; EMORY D. WARNER, M.D.; JOHN R. CARTER, M.D.
In recent years, coumarin drugs have played an important role in the treatment of thrombo-embolic disease. Despite the widespread use of these drugs, the exact mechanism by which they inhibit thrombosis is unknown.
Since anticoagulant activity, as measured by in vitro methods, is not necessarily synonymous with antithrombotic activity, a laboratory test which approximates in vivo clotting conditions would be extremely useful. Blood coagulates when it is placed in a glass tube because the "glass or contact factor" is activated and initiates clotting.1 Blood normally remains fluid within the blood vessels and clots more slowly in a siliconized tube
HOAK JC, CONNOR WE, WARNER ED, CARTER JR. THE ANTITHROMBOTIC PROPERTIES OF COUMARIN DRUGS12. Ann Intern Med. 1961;54:73–81. doi: 10.7326/0003-4819-54-1-73
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Published: Ann Intern Med. 1961;54(1):73-81.
Cardiology, Hospital Medicine.
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