R. G. LOUDON, M.B., CH.B., M.R.C.P.E.; ROY A. LAWSON JR., M.D.
Disseminated north american blastomycosis is a relatively rare disease, which is generally fatal if untreated. Lesions may occur in the lungs, skin, genitourinary tract, soft tissues, bones, and central nervous system. The causative organism, Blastomyces dermatitidis, is highly sensitive to amphotericin B in vitro and in the experimental animal (1-3). Various authors have reported good results in cases of disseminated blastomycosis treated with intravenous amphotericin B (2, 4, 5). In the case reported here, the patient apparently made a good recovery from disseminated blastomycosis following a course of amphotericin B, but subsequently
suffered two neurological relapses, although no neurological signs
LOUDON RG, LAWSON RA. Systemic Blastomycosis: Recurrent Neurological Relapse in a Case Treated with Amphotericin B. Ann Intern Med. 1961;55:139–147. doi: https://doi.org/10.7326/0003-4819-55-1-139
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Published: Ann Intern Med. 1961;55(1):139-147.
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