THOMAS W. GREEN, M.D.; WAVERLY S. GREEN JR., M.D.
Hereditary spherocytosis is a disease characterized by the inherited abnormality of spherocytic red cells, associated with varying degrees of hemolytic anemia and jaundice. Splenectomy in this disorder is usually effective in causing a cessation of the excessive red cell destruction and relieving the anemia and jaundice. If it is performed early in the course of the disease subsequent disability, including biliary tract complications, is eliminated. It is generally agreed that splenectomy is necessary when anemia, jaundice, and hemolytic or aplastic crises are troublesome (1). However, it has not been emphasized that complications of this disease may shorten life expectancy, and
GREEN TW, GREEN WS. Hereditary Spherocytosis with Fatal Complications: Necessity of Elective Splenectomy Early in the Disease. Ann Intern Med. 1961;55:155–157. doi: 10.7326/0003-4819-55-1-155
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Published: Ann Intern Med. 1961;55(1):155-157.
Hematology/Oncology, Red Cell Disorders.
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