GEORGE C. GRIFFITH, M.D., F.A.C.P.
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As a cardiologist, I have been especially interested in the protection against heart attacks that "femaleness" apparently confers upon women during the childbearing years. Under the age of 40, coronary atherosclerosis is from ten to 40 times as frequent in men as in women, and coronary occlusion is virtually unknown in women under 40. In young women, when estrogen production is high, the serum lipid pattern is nonatherogenic, i.e., total cholesterol is low, and cholesterol : phospholipid and beta : alpha-lipoprotein cholesterol ratios also are low.
Some years ago, in a paper entitled "Oophorectomy and Cardiovascular Tissues," I reviewed the
GRIFFITH GC. The Penalty of Being a Male. Ann Intern Med. 1961;55:166–168. doi: 10.7326/0003-4819-55-1-166
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Published: Ann Intern Med. 1961;55(1):166-168.
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