STEWART G. TUTTLE, M.D.; FERNANDO RUFIN, M.D.; AGOSTINHO BETTARELLO, M.D.
Heartburn is a subjective complaint and, as a descriptive term, suffers from lack of specificity. It is frequently used to describe any form of anterior chest discomfort except the classic oppressive pain of angina pectoris; we have seen the word used to enumerate sharp subaxillary shooting pains and suprapubic aching. Our definition as applied to the subjects in this study is more limited: heartburn, in our opinion, is a painful burning sensation located retrosternally in the midline between the xiphoid process and the manubrium. Its duration is variable, but it always has a moving quality. It may radiate to the
TUTTLE SG, RUFIN F, BETTARELLO A. The Physiology of Heartburn. Ann Intern Med. ;55:292–300. doi: 10.7326/0003-4819-55-2-292
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Published: Ann Intern Med. 1961;55(2):292-300.
Esophageal Disorders, Gastroenterology/Hepatology, Gastroesophageal Reflux Disease, Hospital Medicine, Peptic Disease.
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