ELLARD M. YOW, M.D., F.A.C.P.; JAMES C. BRENNAN, M.B., B.CH.; M. H. NATHAN, M.D.; LOUIS ISRAEL, M.S.
The symptoms of brucellosis in human beings usually disappear within a year whether or not the patient is treated. Occasionally the brucellae may remain viable in reticuloendothelial cells or in granulomata for long periods without producing clinical symptoms. In a few patients, the infection may be sufficiently active either chronically or intermittently to produce local and systemic evidence of infection (1, 2).
The persistence of organisms in foci within the central nervous system, bones and joints, liver, heart, kidney, prostate, and eye has been reported or reviewed by Spink (1). Other reports reveal 11 patients in whom there were definite
YOW EM, BRENNAN JC, NATHAN MH, et al. Calcified Granulomata of the Spleen in Long Standing Brucellar Infection: A Report of a Case of Twenty-five Years' Duration. Ann Intern Med. 1961;55:307–313. doi: https://doi.org/10.7326/0003-4819-55-2-307
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Published: Ann Intern Med. 1961;55(2):307-313.
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