ABNER J. DELMAN, M.D.; JEROME G. PORUSH, M.D.; ALVIN D. SCHWARTZ, M.D.
The clinical manifestations of panhypopituitarism secondary to destruction of the adenohypophysis are well known. After its original description by Simmonds (1) in 1914, panhypopituitarism was the subject of many case reports and reviews (2-5). Marked insufficiency of the target glands and profound cachexia were stressed. Sheehan and Murdoch (6, 7) first emphasized that most patients with pituitary insufficiency are not cachetic and that there is a wide clinical spectrum of pituitary dysfunction. Hypopituitarism may vary from mild involvement of one or more of the target glands to severe insufficiency of all three principal organs (6-8). The clinical course may range
DELMAN AJ, PORUSH JG, SCHWARTZ AD. Hypogonadotrophic Hypogonadism Simulating Turner's Syndrome. Ann Intern Med. ;55:471–478. doi: 10.7326/0003-4819-55-3-471
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Published: Ann Intern Med. 1961;55(3):471-478.
Endocrine and Metabolism, Hospital Medicine.
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