HERBERT C. SWEET, M.D., F.A.C.P.; JOHN P. WYATT, M.D.; ANDREW J. FRITSCH, M.D.; PETER W. KINSELLA, M.D.
Distinctive anatomical patterns have been described for pulmonary emphysema in recent years, due principally to the increased use of the macrosection technique. These have been grouped into centrilobular (1, 2), and panlobular (3) [panacinar] (4) types, and a group combining the characteristics of the two.
The anatomic differences between centrilobular and panlobular emphysema depend upon the recognition of the secondary lobule of Miller (5). The respiratory bronchioles, accompanied by arterioles, are situated in the central portion of the secondary lobule; the pulmonary venules are found in the connective tissue of the periphery.
The earliest centrilobular lesion consists of ectasia, then
SWEET HC, WYATT JP, FRITSCH AJ, et al. Panlobular and Centrilobular Emphysema: Correlation of Clinical Findings with Pathologic Patterns. Ann Intern Med. 1961;55:565–581. doi: 10.7326/0003-4819-55-4-565
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Published: Ann Intern Med. 1961;55(4):565-581.
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