NORMAN N. COHEN, M.D.; H. PHELPS POTTER JR., M.D.; GEORGE N. BOWERS JR., M.D.
Laboratory evaluation of hepatocellular damage has been aided in recent years by the development of new methods for measuring serum activities of enzymes released from injured liver cells. One of these enzymes is isocitric dehydrogenase; in the Kreb's cycle, this enzyme catalyzes the dehydrogenation and decarboxylation of isocitrate to alpha-ketoglutarate (1). The method for the determination of serum isocitric dehydrogenase offers some technical advantages when it is compared with the spectrophotometric methods for the serum transaminases [glutamic-oxaloacetic and glutamic-pyruvic transaminases] (2). Furthermore, although the liver and the myocardium show comparable activities of isocitric dehydrogenase, increased activity of this enzyme in
COHEN NN, POTTER HP, BOWERS GN. An Evaluation of Isocitric Dehydrogenase in Liver Disease. Ann Intern Med. 1961;55:604–609. doi: 10.7326/0003-4819-55-4-604
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Published: Ann Intern Med. 1961;55(4):604-609.
Gastroenterology/Hepatology, Liver Disease.
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