BOY FRAME, M.D., F.A.C.P.; HAROLD M. FROST, M.D.; ROBERT S. ORMOND, M.D.; ROBERT B. HUNTER, M.D.
Three patients with a unique coarsening and sponge-like appearance in the X rays of the axial skeleton have been observed in the past year. These changes occurred primarily in the cervical spine and to a lesser extent in the lumbar spine, the pelves, and the ribs. The long bones of the appendicular skeleton were not involved. Symptomatology relating to the skeletal system was minimal and the patients were in excellent general health. Histologic study of open iliac crest biopsies demonstrated the presence of an increased number of wide osteoid seams compatible with the diagnosis of osteomalacia in spite of the
FRAME B, FROST HM, ORMOND RS, et al. Atypical Osteomalacia Involving the Axial Skeleton. Ann Intern Med. 1961;55:632–639. doi: 10.7326/0003-4819-55-4-632
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Published: Ann Intern Med. 1961;55(4):632-639.
Endocrine and Metabolism, Metabolic Bone Disorders.
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