B. J. KENNEDY, M.D., F.A.C.P.; ATHANASIOS THEOLOGIDES, M.D.
The utilization of pyrimidines in the synthesis of nucleic acids has resulted in investigation of their chemical analogs in the chemotherapy of advanced malignancies. A trial of fluorinated pyrimidines in animal tumors was based on the profound biological effect obtained by other compounds when hydrogen was substituted by fluorine. The most potent fluorinated pyrimidine was 5-fluorouracil [Figure 1] (1). Clinical trials in metastatic human cancers have demonstrated objective improvements in a variety of tumors (2-21). The present report is a further evaluation of this agent in an attempt to establish the role of 5-fluorouracil in cancer therapy.
KENNEDY BJ, THEOLOGIDES A. The Role of 5-Fluorouracil in Malignant Disease. Ann Intern Med. 1961;55:719–730. doi: 10.7326/0003-4819-55-5-719
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Published: Ann Intern Med. 1961;55(5):719-730.
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