JOHN A. SPITTELL JR., M.D.; CHRIS A. PASCUZZI, M.D.; JOHN H. THOMPSON JR., PH.D.; CHARLES A. OWEN JR., M.D.
What part, if any, thrombosis plays in the development of arteriosclerosis is still unsettled; however, there is agreement that thrombosis is the terminal event in the arterial occlusion of the extremity affected by arteriosclerosis obliterans. Pathologic study of the arteries of limbs amputated for advanced arteriosclerosis obliterans has shown that thrombosis is responsible for at least part of the arterial occlusion in all (1).Within the group of persons with arteriosclerosis obliterans are patients whose course is a chronic one, their only symptom being intermittent claudication; the course of other patients, however, is complicated by sudden arterial occlusion often resulting in
SPITTELL JA, PASCUZZI CA, THOMPSON JH, OWEN CA. Accelerated Thromboplastin Generation in Acute Arterial Occlusion Complicating Arteriosclerosis Obliterans. Ann Intern Med. ;55:765–771. doi: 10.7326/0003-4819-55-5-765
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Published: Ann Intern Med. 1961;55(5):765-771.
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