KENT G. KIMBALL, M.D.
Amyloidosis is a disease of unknown etiology characterized by deposits in various tissues of a glycoprotein material immunologically related to normal gamma globulin (1). It occurs as localized amyloidosis, generalized "primary" amyloidosis without any predisposing disease, and generalized "secondary" amyloidosis with predisposing disease (2).
Localized amyloidosis occurs in the respiratory tract, the bladder, urethra, skin, oral mucosa, and occasionally in squamous papillomas and basal cell carcinomas of the skin (2). Primary amyloidosis consists of amyloid of slightly different staining characteristics from those of the secondary variety. It involves primarily the liver, heart, and spleen, and to a lesser extent the
KIMBALL KG. Amyloidosis in Association with Neoplastic Disease: Report of an Unusual Case and Clinicopathological Experience at Memorial Center for Cancer and Allied Diseases during Eleven Years (1948-1958). Ann Intern Med. 1961;55:958–974. doi: https://doi.org/10.7326/0003-4819-55-6-958
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Published: Ann Intern Med. 1961;55(6):958-974.
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