MARTIN GOLDBERG, M.D.; MARTIN REIVICH, M.D.
Among the endocrine disorders impaired water excretion is a well-documented characteristic of adrenal and pituitary insufficiency (1). An inability to normally excrete a water load in primary myxedema has been described (2-4), but there appears to be disagreement as to both the frequency of its occurrence and the magnitude of the defect. The underlying mechanism for this abnormal antidiuresis has not been clearly delineated. Vogt (3) attributed the cause to defective adrenocorticotropic hormone production in response to a water load, but Crispell, Parson, and Sprinkle (2) could not correct the defect in water excretion in four patients with myxedema by
GOLDBERG M, REIVICH M. Studies on the Mechanism of Hyponatremia and Impaired Water Excretion in Myxedema. Ann Intern Med. 1962;56:120–130. doi: 10.7326/0003-4819-56-1-120
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Published: Ann Intern Med. 1962;56(1):120-130.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology, Thyroid Disorders.
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