SHERMAN M. MELLINKOFF, M.D., F.A.C.P.; RICHARD W. SNODGRASS, M.D.; ARTHUR D. SCHWABE, M.D.; JAMES F. MEAD, PH.D.; HENRY E. WEIMER, PH.D.; MARJORIE FRANKLAND, A.B.
Clinical and laboratory features of familial Mediterranean fever have been described by many authors (1-5). A comprehensive and thoughtful analysis of the medical problem and clarification of terminology in the world-wide literature were provided in 1958 by Heller, Sohar, and Sherf (1), stimulating renewed interest in this disease.
In brief, the patients are almost always of Mediterranean ancestry and inherit a tendency to suffer from recurrent short attacks of fever, usually accompanied by peritonitis, pleuritis, arthritis, or dermatitis (6). Ultimately a large number develop amyloidosis, which is apparently not well correlated with the duration or frequency of the febrile episodes
MELLINKOFF SM, SNODGRASS RW, SCHWABE AD, et al. Familial Mediterranean Fever: Plasma Protein Abnormalities, Low-fat Diet, and Possible Implications in Pathogenesis. Ann Intern Med. 1962;56:171–182. doi: 10.7326/0003-4819-56-2-171
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Published: Ann Intern Med. 1962;56(2):171-182.
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