JOEL B. MANN, M.D.; SEYMOUR ALTERMAN, M.D.; A. GORMAN HILLS, M.D.
Some 20 years ago Albright, Burnett, Smith, and Parson (1) first called attention to a syndrome in which certain skeletal abnormalities coexist with chemical and clinical findings characteristic of hypoparathyroidism. The chemical derangements (hypocalcemia, hyperphosphatemia) found in all three cases originally reported were refractory to correction by administration of parathyroid extract. Parathyroid biopsy obtained from their first patient, after treatment with dihydrotachysterol had corrected the hypocalcemia, disclosed normal parathyroid histology. The authors inferred that the renal tubule was failing to respond to an adequate quantity of circulating parathyroid hormone, and christened the condition "pseudohypoparathyroidism." Subsequently Elrick and others (2), reporting
MANN JB, ALTERMAN S, HILLS AG. Albright's Hereditary Osteodystrophy Comprising Pseudohypoparathyroidism and Pseudo-pseudohypoparathyroidism: With a Report of Two Cases Representing the Complete Syndrome Occurring in Successive Generations. Ann Intern Med. 1962;56:315–342. doi: https://doi.org/10.7326/0003-4819-56-2-315
Download citation file:
Published: Ann Intern Med. 1962;56(2):315-342.
Endocrine and Metabolism, Metabolic Bone Disorders.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use