PAUL D. DOOLAN; MANFORD D. MORRIS, PH.D.; HAROLD A. HARPER, PH.D.
Normally, in a fasting human subject, almost all of the amino acids filtered at the glomerulus are reabsorbed (1). If the filtered load of an amino acid is increased, both the amount reabsorbed as well as that excreted are increased; indeed, in man no clear-cut maximal reabsorptive rate (Tm) has as yet been demonstrated for any amino acid (2). It follows that a major determinant of the amount of an amino acid excreted is the amount filtered, and justification can thus be made for defining an aminoaciduria in terms of the fraction of the filtered load which is excreted. In
DOOLAN PD, MORRIS MD, HARPER HA. Aminoaciduria in an Elderly Man with the Nephrotic Syndrome and in a Young Man with a Variant of the Fanconi Syndrome. Ann Intern Med. 1962;56:448–456. doi: 10.7326/0003-4819-56-3-448
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Published: Ann Intern Med. 1962;56(3):448-456.
Geriatric Medicine, Nephrology, Nephrotic Syndrome.
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