JACQUES M. SINGER, M.D.; CHARLES M. PLOTZ, M.D., F.A.C.P.; FRANCISCO M. PERALTA, M.D.; HAROLD C. LYONS, M.D.
The use of particulate carrier agglutination methods has made possible the serological detection of serum macroglobulins which interact with human or animal gamma globulin (1). These macroglobulins, present with great frequency in the sera of patients with rheumatoid arthritis, have been called "rheumatoid factors" (2-4). Similar macroglobulins are also present in many other disease states, including systemic lupus erythematosus, sarcoidosis, syphilis, and cirrhosis of the liver (5-9).
Positive "rheumatoid factor" agglutination tests have also been obtained with sera from some patients with chronic pulmonary tuberculosis (9-11). It was the purpose of this study to determine whether such positive "rheumatoid factor"
SINGER JM, PLOTZ CM, PERALTA FM, et al. The Presence of Anti-gamma Globulin Factors in Sera of Patients with Active Pulmonary Tuberculosis. Ann Intern Med. 1962;56:545–552. doi: https://doi.org/10.7326/0003-4819-56-4-545
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Published: Ann Intern Med. 1962;56(4):545-552.
Infectious Disease, Mycobacterial Infections, Pulmonary Tuberculosis, Pulmonary/Critical Care.
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