JEROME E. COHN, M.D.; HIROSHI KUIDA, M.D.
The alveolar hypoventilation syndrome, characterized by arterial hypercapnia, develops when alveolar ventilation falls below a critical value. Fishman, Turino, and Bergofsky reviewed the clinical, pathophysiological, and biochemical features of the syndrome and many of the disease processes with which it may be associated (1). Usually hypoventilation occurs secondary to dysfunction of the lung, thoracic bellows, or motor nerves. "Primary alveolar hypoventilation," a rare condition, is ascribed to diminished responsiveness of the respiratory center itself (Table 1). This diagnosis can be made only when hypoventilation occurs in the absence of functional abnormality of the lungs, chest muscles, and motor nerves. Rodman
COHN JE, KUIDA H. Primary Alveolar Hypoventilation Associated with Western Equine Encephalitis. Ann Intern Med. 1962;56:633–644. doi: https://doi.org/10.7326/0003-4819-56-4-633
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Published: Ann Intern Med. 1962;56(4):633-644.
Infectious Disease, Pulmonary/Critical Care.
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