M. McGregor, M.D.
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It is generally believed that angina pectoris results from a temporary discrepancy between the oxygen requirement of the myocardium and the available supply. The only drugs capable of giving striking relief are the nitrites, and it has been accepted widely that their effect is the result of active coronary vasodilatation. Relief, however, might be achieved in several other ways. Flow might be increased by prolongation of diastole or increase in perfusion pressure. Oxygen demand might be reduced by reduction in mechanical work or by change in myocardial metabolism. Evidence that the effect of nitroglycerin is probably not primarily due to
McGregor M. The Relief of Angina Pectoris: Mechanism of Action of Coronary "Vasodilators.". Ann Intern Med. ;56:669. doi: 10.7326/0003-4819-56-4-669_2
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Published: Ann Intern Med. 1962;56(4):669.
Cardiology, Coronary Heart Disease.
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