N. P. Christy, M.D.; W. D. Drucker, M.D.
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Adrenocorticotropic activity is not demonstrable in normal human plasma by current methods, but maximal stimulation of pituitary ACTH release (adrenalectomy, Addison's disease) results in measurable levels. When similar assay methods are applied to the plasma of patients with Cushing's disease (bilateral adrenal cortical hyperplasia), they fail to demonstrate adrenocorticotropic activity until complete adrenalectomy is performed. In order to implicate an adrenocorticotropin in the pathogenesis of this disorder, demonstration of increased activity in the plasma of the untreated patient is essential. In 1957, Jailer and colleagues showed an abnormal adrenocorticotropin in patients with the untreated disease, but its nature and origin
Christy NP, Drucker WD. The Essential Role of the Anterior Pituitary in the Pathogenesis of Cushing's Disease.. Ann Intern Med. 1962;56:673. doi: https://doi.org/10.7326/0003-4819-56-4-673_3
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Published: Ann Intern Med. 1962;56(4):673.
Adrenal Disorders, Endocrine and Metabolism.
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