P. C. Johnson, M.D., F.A.C.P.
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Mammalian erythrocytes, being devoid of mitochondria but containing both the hexose monophosphate shunt pathway and the Embden-Meyerhof pathway of glucose oxidation, make convenient preparation for the study of the effects that thyroid hormone has on these two metabolic pathways. Certain enzymes of the hexose monophosphate shunt pathway have been shown to be increased in erythrocytes from thyroid-treated animals and in thyrotoxicosis.
Using C-14 glucose in vitro, we have found that the hexose monophosphate shunt pathway of glucose oxidation is depressed to 27 ± 6% (mean ± SE) of normal in ten thyrotoxic individuals and three normal persons treated for two
Johnson PC. A Possible Site of Action of Thyroid Hormone.. Ann Intern Med. 1962;56:676. doi: 10.7326/0003-4819-56-4-676_1
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Published: Ann Intern Med. 1962;56(4):676.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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