W. S. Middleton, M.D., M.A.C.P.
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The designation of a group of disorders with the common denominator of a disruption of the ground substance as collagen diseases has revived interest in the physiology, pathogenesis, pathology, and clinical significance of the connective tissue, as well as in its physical, enzymic, and physiological chemistry. Moreover, certain of these diseases have assumed a broader importance in the recognition of their systemic extension. Scleroderma, for example, can no longer be considered as purely a dermatologic disorder, since its systemic manifestations may anticipate the cutaneous lesions and exceed them in gravity. The term "diffuse systemic sclerosis" should replace the limited terms
Middleton WS. Diffuse Systemic Sclerosis. Alfred Stengel Memorial Lecture.. Ann Intern Med. ;56:682. doi: 10.7326/0003-4819-56-4-682_2
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Published: Ann Intern Med. 1962;56(4):682.
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