G. Pincus, M.D.
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Two major causes of infertility, anovulation and ovum blighting, may be imitated experimentally in animals by ovulation inhibition and anti-progestational compounds. Extensive investigations of natural and synthetic steroids in animals disclose: (a) highly potent ovulation inhibitors which are also active progestins; (b) certain substances exhibiting potency greater in oral administration than by parenteral administration; (c) anti-progestins of two types, estrogenic and competitive inhibitors; and (d) significant ovum blighting by anti-progestins.
Clinical trials with two highly active steroidal ovulation inhibitors, norethynodrel and ethynodiol diacetate confirm studies made on animals which indicate the superior potency of the latter, particularly when orally administered.
Pincus G. Fertility and Conception Control.. Ann Intern Med. 1962;56:682. doi: https://doi.org/10.7326/0003-4819-56-4-682_3
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Published: Ann Intern Med. 1962;56(4):682.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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