M. A. Amundsen, M.D.; J. A. Spittell Jr., M.D., F.A.C.P.; J. H. Thompson Jr., Ph.D.; C. A. Owen Jr., M.D.
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Because accelerated thromboplastin generation has been demonstrated by the "retarded" thromboplastin generation test (TGT), in certain persons with arterial and venous thrombosis, a study was made of the coagulation changes occurring in the postoperative state and in association with malignant lesions, two conditions in which thromboembolism is known to occur.
Twenty-five subjects with normal thromboplastin generation underwent a variety of surgical procedures. In each case, accelerated thromboplastin generation occurred by the sixth postoperative day. Thromboplastin generation also was evaluated in a group of 30 patients with malignant lesions which included tumors of the breast, lung, and abdominal viscera. Thromboplastin generation
Amundsen MA, Spittell JA, Thompson JH, et al. Hypercoagulability Associated with Malignancy and the Postoperative State: Evidence of Elevated Antihemophilic Globulin-like Activity (AHG).. Ann Intern Med. 1962;56:683. doi: https://doi.org/10.7326/0003-4819-56-4-683_3
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Published: Ann Intern Med. 1962;56(4):683.
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