D. J. Demis, M.D.
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Twenty-three patients with mastocytosis have been evaluated. In addition to skin lesions (urticaria pigmentosa), approximately one-third of the patients were noted to have associated findings of bone lesions and organomegaly, and symptoms including flushing, pruritus, gastrointestinal complaints and peptic ulceration, headache, malaise, tachycardia, and shock. The consistency of these symptoms and findings reveals their occurrence to be more than a chance event and suggests the existence of a true syndrome associated with mastocytosis.
The basic pathologic change is one of infiltration by tissue mast cells known to contain large stores of histamine. Homogenates were prepared from biopsies of skin lesions
Demis DJ. The Mastocytosis Syndrome: Clinical and Biochemical Studies.. Ann Intern Med. 1962;56:684. doi: https://doi.org/10.7326/0003-4819-56-4-684_3
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Published: Ann Intern Med. 1962;56(4):684.
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