C. M. Leevy, M.D., F.A.C.P.; H. Baker, Ph.D.; O. Frank, Ph.D.; H. Ziffner, M.D.
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Previous studies in our laboratory showed flushing doses of cyanocobalamine displaced hepatic B12 and an alkaline resistant thermostable substance (Factor X), both of which supported growth of microorganisms requiring B12. The present communication reports results of further investigations on the occurrence, nature, and clinical effects of Factor X.
Hepatic venous serum exhibited no B12 activity following alkaline hydrolysis, but despite such treatment, serum obtained after administering 100 micrograms of B12 permitted growth of Lactobacillus leichmannii, Escherichia coli 113-3, Euglena gracilis, and Ochromonas malhamensis. Maximum displacement of Factor X occurred at 30 minutes; its serum level rapidly declined during the succeeding
Leevy CM, Baker H, Frank O, et al. Observations on an Alkali Resistant Thermostable Hemopoietic Principle in Liver.. Ann Intern Med. 1962;56:686. doi: 10.7326/0003-4819-56-4-686_1
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Published: Ann Intern Med. 1962;56(4):686.
Gastroenterology/Hepatology, Liver Disease.
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