B. Tynes, M.D.; J. P. Utz, M.D., F.A.C.P.
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Twenty-six adult carriers of Salmonella, who incidentally were the source of over 150 cases of Salmonella infection with two deaths, are the basis of this study. Nearly all had received antibiotics previously. Antibiotic regimens at the Clinical Center included prolonged treatment with tetracycline and chloramphenicol, paramomycin, kanamycin, and up to 1,860 million units of penicillin plus probenecid.
With antibiotics alone, only the three carriers without demonstrable gall stones were cured. Cholecystectomy alone cured only five of nine patients, whereas all nine treated by cholecystectomy combined with antibiotic therapy were cured.
Cultures of bile and the gall bladder were positive in
Tynes B, Utz JP. Factors Influencing the Treatment of Salmonella Carriers.. Ann Intern Med. 1962;56:692. doi: https://doi.org/10.7326/0003-4819-56-4-692_1
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Published: Ann Intern Med. 1962;56(4):692.
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