T. E. Woodward, M.D., F.A.C.P.
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Typhoid fever continues to ravage mankind, and, although its attacks have been combatted therapeutically, serious complications and death occur, there is no completely effective vaccine, and the carrier problem is unsolved.
Studies in volunteers, designed to ascertain the effectiveness of typhoid vaccine, have permitted critical appraisal of the clinical disease, its variability, and physiologic alterations. Bacteremia often occurs prior to the onset of symptoms, and response to therapy is prompt. There appears to be no relationship between the height of the antibody titer (O and H) and the ability to isolate Salmonella typhosa from the blood during first infection or
Woodward TE. Typhoid Fever: Pathogenesis, Physiologic Abnormalities, and the Carrier Problem.. Ann Intern Med. 1962;56:693. doi: https://doi.org/10.7326/0003-4819-56-4-693_1
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Published: Ann Intern Med. 1962;56(4):693.
DOI: 10.7326/0003-4819-56-4-693_1
Infectious Disease.
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