M. E. Shils, M.D., SC.D.
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Since the introduction of tetracycline antibiotics into clinical medicine, sporadic reports have appeared in which a proportion of patients receiving this type of drug have developed increases of varying degree in the blood urea nitrogen or non-protein nitrogen. Some insight into the cause of the azotemia was afforded by the metabolic studies of Gabuzda and colleagues (Arch. Intern. Med. 101: 476, 1958) who noted significant increases in urinary nitrogen in malnourished subjects given various tetracyclines. This observation has been confirmed by Faloon and co-workers and by ourselves.
Because of dependence on the kidney for elimination of this group of antibiotics,
Shils ME. Renal Disease and the Metabolic Effects of Tetracycline.. Ann Intern Med. 1962;56:698. doi: 10.7326/0003-4819-56-4-698_1
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Published: Ann Intern Med. 1962;56(4):698.
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