FRANK H. DAILEY, M.D.; PASQUALE D. GENOVESE, M.D., F.A.C.P.; ROY H. BEHNKE, M.D.
The clinical syndrome of patent ductus arteriosus with reversal of flow is specifically different from that of the classic, uncomplicated patent ductus. For this reason and because of its relative infrequency it may present a difficult diagnostic problem.
In 1925 Holman (1) reported the abstracts of 28 cases of patent ductus previously collected by Halsted, and on the basis of the autopsy findings felt that 16 of the patients had predominantly right to left shunts. The earliest of these cases, reported by Luys in 1856, suffered from lifelong dyspnea, was cyanotic, and had no murmur. Following this review the literature
DAILEY FH, GENOVESE PD, BEHNKE RH. Patent Ductus Arteriosus with Reversal of Flow in Adults. Ann Intern Med. ;56:865–882. doi: 10.7326/0003-4819-56-6-865
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Published: Ann Intern Med. 1962;56(6):865-882.
Cardiology, Hospital Medicine.
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