JAMES A. PITCOCK, M.D.; EDWARD H. REINHARD, M.D., F.A.C.P.; BERTRAM W. JUSTUS, M.D.; ROBERT S. MENDELSOHN, M.D.
Idiopathic myelofibrosis is commonly described as characterized by splenomegaly, replacement of the bone marrow by fibrous tissue, a leuko-erythroblastic peripheral blood picture, and extramedullary hematopoiesis in the tissues. The relationship of this condition to chronic granulocytic leukemia remains confused because of the existence of cases which appear to be either transitional or intermediate between these 2 conditions. The use of a broad classification, such as myeloproliferative syndrome, serves to point out the similarities of this group of diseases, but the presence of histologically demonstrable fibrous tissue in the bone marrow, whether or not it is of fundamental importance, continues to
PITCOCK JA, REINHARD EH, JUSTUS BW, et al. A Clinical and Pathological Study of Seventy Cases of Myelofibrosis. Ann Intern Med. 1962;57:73–84. doi: https://doi.org/10.7326/0003-4819-57-1-73
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Published: Ann Intern Med. 1962;57(1):73-84.
Hematology/Oncology, Red Cell Disorders.
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