ROBERT W. COLMAN, M.D.; HARVEY M. SHEIN, M.D.
Alcoholics dying in hepatic failure may be grouped into 3 distinct clinical categories, each correlated with a predominant change in liver histology: portal fibrosis, necrosis, or fatty infiltration (1). The fatal outcome in patients with fibrosis or necrosis may be presumed to be lack of sufficient functioning hepatic tissue. On the other hand, the cause of death is often obscure in those patients whose livers show only fatty infiltration, because it has been shown that fatty change per se does not interfere with most hepatic functions.
A case is reported of acute hepatic failure in a young female alcoholic whose
COLMAN RW, SHEIN HM. Leukemoid Reaction, Hyperuricemia, and Severe Hyperpyrexia Complicating a Fatal Case of Acute Fatty Liver of the Alcoholic. Ann Intern Med. 1962;57:110–115. doi: 10.7326/0003-4819-57-1-110
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Published: Ann Intern Med. 1962;57(1):110-115.
Gastroenterology/Hepatology, Liver Disease.
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