WILLIAM A. REYNOLDS, M.D.
Sickle cell-thalassemia disease, or microdrepanocytosis, is a hemoglobinopathy resulting from the combination of a sickle cell gene and a thalassemia gene. In 1945 Silvestroni and Bianco were the first to describe this disease as a clinical, hematologic, and genetic entity as found in a number of Sicilian families (1-5). In a survey of the literature through 1956, Brown and Ober (6) collected 34 cases and added one case of their own. Up to the present more than 130 cases have been reported in the world medical literature. In addition at least 14 cases previously described as sickle cell anemia better
REYNOLDS WA. Benign Sickle Cell-Thalassemia Disease and Cryptic Thalassemia in a Negro Family. Ann Intern Med. 1962;57:121–128. doi: 10.7326/0003-4819-57-1-121
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Published: Ann Intern Med. 1962;57(1):121-128.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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