WILLIAM R. MCCABE, M.D.; JOSEPH J. LAPORTE
The paramount importance of Staphylococcus aureus as a cause of hospital-acquired infections is well recognized. Despite extensive investigation, the pathogenesis and the nature and importance of host defenses in staphylococcal infections have not been clearly defined. In fact there is experimental evidence that the usually protective mechanism of phagocytosis may actually perpetuate staphylococcal bacteremia (1, 2). Studies of bacteremia in rabbits suggest that although pathogenic staphylococci are readily ingested by phagocytic leukocytes, some continue to reside undamaged in this intracellular location and are provided a protective environment which hinders their destruction by other host defenses (3).
This report demonstrates that
MCCABE WR, LAPORTE JJ. Intracellular Bacteria in the Peripheral Blood in Staphylococcal Bacteremia. Ann Intern Med. ;57:141–143. doi: 10.7326/0003-4819-57-1-141
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Published: Ann Intern Med. 1962;57(1):141-143.
Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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