BURTON D. COHEN, M.D.
Several disease states share with diabetes mellitus a decreased rate of decline of blood glucose manifested by an elevated fasting blood sugar and an abnormal glucose tolerance. These include hepatic cirrhosis (1), malignancy (2, 3), eclampsia (4, 5), renal disease (6, 7), essential hyperlipemia (8), and a variety of endocrine disorders such as Cushing's syndrome, acromegaly, thyrotoxicosis, and pheochromocytoma (9). This paper attempts to define the site of this metabolic defect in patients with renal disease.
In 1916 Myers and co-workers (10, 11) observed fasting hyperglycemia in 20 per cent of patients with renal disease. This finding, subsequently confirmed by
COHEN BD. Abnormal Carbohydrate Metabolism in Renal Disease: Blood Glucose Unresponsiveness to Hypoglycemia, Epinephrine, and Glucagon. Ann Intern Med. 1962;57:204–213. doi: 10.7326/0003-4819-57-2-204
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Published: Ann Intern Med. 1962;57(2_Part_1):204-213.
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