GEORGE C. GRIFFITH, M.D., F.A.C.P.; DAVID LEAK, M.B., M.R.C.P. (EDIN.); BALAKRISHNA HEGDE, G.C.I.M., M.S. (MED.)
Although the value of anticoagulants in the short-term treatment of acute myocardial infarction is still not settled, the majority of authors working in many different parts of the world have repeatedly claimed that anticoagulants reduce the mortality rate by one-half to one-third (1, 2). In the case of such apparent unanimity, it may seem difficult to justify still another examination of this problem, yet we feel that there are a number of points worthy of further study.
Firstly, the belief that there is an optimal level of anticoagulant therapy which produces a depression of the prothrombin level within a so-called
GRIFFITH GC, LEAK D, HEGDE B. Conservative Anticoagulant Therapy of Acute Myocardial Infarction. Ann Intern Med. ;57:254–265. doi: 10.7326/0003-4819-57-2-254
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Published: Ann Intern Med. 1962;57(2_Part_1):254-265.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine.
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