JOSEPH W. ESCHBACH, M.D.; JOSEPH A. RINALDO JR., M.D.
The carcinoid syndrome is characterized by vasomotor phenomena, bronchoconstriction, intestinal hyperperistalsis, and stenosis and insufficieny of the pulmonary and tricuspid valves due to the effects of excessive circulating 5-hydroxytryptamine (serotonin). This symptom complex is rarely found in the absence of metastatic carcinoid tumors. The classical form is not always present. Although isolated carcinoid tumors of the gastrointestinal tract are not uncommon, liver metastases with hyperserotonemia are unusual. Their occurrence in more than one member of the same family has not been reported. This report describes a woman with a well-documented carcinoid syndrome whose brother also had metastatic carcinoid tumor and
ESCHBACH JW, RINALDO JA. Metastatic Carcinoid: A Familial Occurrence. Ann Intern Med. 1962;57:647–650. doi: https://doi.org/10.7326/0003-4819-57-4-647
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Published: Ann Intern Med. 1962;57(4):647-650.
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