MARTIN E. FINK, M.D.; PAUL CALABRESI, M.D.
The large number of myelosuppressive drugs currently used in the treatment of patients with neoplastic disease necessitates more accurate evaluation of bone marrow reserve. This is important because the condition of individual marrow reserves may vary considerably, particularly in patients who have had previous surgery, irradiation, or chemotherapy, and in those who have either depletion of proteins or myelophthisis.
The usual criteria for determining drug dosages and intervals between treatments have been primarily peripheral blood studies and, less frequently, bone marrow aspirations. Both techniques have proven inadequate because they do not predict the response of the functional bone marrow reserve
FINK ME, CALABRESI P. The Granulocyte Response to an Endotoxin (Pyrexal) as a Measure of Functional Marrow Reserve in Cancer Chemotherapy. Ann Intern Med. 1962;57:732–742. doi: 10.7326/0003-4819-57-5-732
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Published: Ann Intern Med. 1962;57(5):732-742.
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