LAURENCE H. KYLE, M.D., F.A.C.P.; WILLIAM R. BEISEL; JOHN J. CANARY, M.D.
Since the introduction of the measurement of phosphate excretion as a diagnostic test in parathyroid dysfunction, data supplied from a number of laboratories have stimulated discussion along 2 major lines:  the best method of measuring phosphate excretion, and  evaluation of the value of hyperphosphaturia in the diagnosis of hyperparathyroidism. Recommended methods of measuring phosphate excretion include percentage of tubular reabsorption of phosphate, the "phosphate excretion index," measurement of the tubular maximum for phosphate [TmP], and phosphate clearance [Cp] (1-5). Our laboratories have presented data attesting to the superiority of phosphate clearance (4,6). There has been a wide range
KYLE LH, BEISEL WR, CANARY JJ. Evaluation of the Relative Value of Diagnostic Tests in Hyperparathyroidism. Ann Intern Med. ;57:957–962. doi: 10.7326/0003-4819-57-6-957
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Published: Ann Intern Med. 1962;57(6):957-962.
Endocrine and Metabolism, Parathyroid Disorders.
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