JOHN S. GRAETTINGER, M.D., F.A.C.P.; ROBERT L. PARSONS, M.D.; JAMES A. CAMPBELL, M.D., F.A.C.P.
Castle and Minot emphasized in 1936 that anemic patients "may show, while at complete rest, very little discomfort from a reduction of the red blood cells and hemoglobin values to about one-fifth of normal" (1). Blumgart and Altschule, in a major compilation of the data concerning the adjustments of the cardiovascular system to chronic anemia (2), emphasized that the bulk of the data available were obtained from patients in the basal state. The presently available hemodynamic data (3-7), with few exceptions (8-10), have been measured in resting patients, and it has been widely accepted since the work of Brannon, Merrill,
GRAETTINGER JS, PARSONS RL, CAMPBELL JA. A Correlation of Clinical and Hemodynamic Studies in Patients with Mild and Severe Anemia with and without Congestive Failure. Ann Intern Med. 1963;58:617–626. doi: 10.7326/0003-4819-58-4-617
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Published: Ann Intern Med. 1963;58(4):617-626.
Hematology/Oncology, Red Cell Disorders.
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