DeW. S. Goodman, M.D.
This content is PDF only. Please click on the PDF icon to access.
Recent studies on cholesterol biosynthesis have defined almost the entire reaction sequence. Three molecules of acetate first combine to form the key 6-carbon intermediate, mevalonic acid. Decarboxylation of mevalonic acid provides a 5-carbon isoprenoid intermediate, 3 molecules of which join to form the 15-carbon farnesyl pyrophosphate. Two molecules of this then combine to form the 30-carbon hydrocarbon squalene. The reaction mechanism of squalene formation is most unusual and without any known biochemical counterpart. During this reaction 1 hydrogen atom attached to carbon 1 of 1 of the 2 molecules of farnesyl pyrophosphate is exchanged for a hydrogen atom from TPNH.
Goodman DS. Cholesterol Biosynthesis and Metabolism.. Ann Intern Med. 1963;58:717–718. doi: 10.7326/0003-4819-58-4-717_3
Download citation file:
Published: Ann Intern Med. 1963;58(4):717-718.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use