T. A. Dull, M.D.; P. H. Henneman, M.D.
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The Imino Acid hydroxyproline occurs in the body almost exclusively in collagen. Twenty-four-urinary total hydroxyproline was measured in 57 subjects on diets devoid of gelatin. Eight normal adults excreted 8 to 40 mg daily, and 15 adults with various diseases not known to involve connective tissue excreted from 8 to 37 mg of total hydroxyproline daily. Eight normal prepubertal children excreted 30 to 103 mg, while 5 children with growth failure excreted 21 to 42 mg daily. Urinary hydroxyproline in 6 hyperthyroid patients ranged from 79 to 440 mg, and in 15 patients with Paget's disease, values from 67 to
Dull TA, Henneman PH. Clinical Significance of Urinary Hydroxyproline.. Ann Intern Med. 1963;58:720. doi: https://doi.org/10.7326/0003-4819-58-4-720_2
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Published: Ann Intern Med. 1963;58(4):720.
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