P. H. Henneman, M.D.; P. F. Maurice, M.D.; L. V. Avioli, M.D.; T. A. Dull, M.D.; C. H. Bastomsky, M.D.; T. N. Lynch, M.D.
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A has been administered to tolerance for 3 to 27 days during complete balance studies on 6 patients with Paget's disease of bone. Within 3 days, there has occurred a decrease in serum, urinary, and fecal calcium with resultant calcium retention. Phosphorus retention resulted from a decrease in fecal excretion despite a slight increase in urinary phosphorus. Although fasting levels of serum magnesium were unchanged, urinary and fecal magnesium decreased with resultant magnesium retention. Calcium47 kinetic analyses in 4 patients revealed increased exchangeable calcium pools, endogenous fecal calcium, and bone resorption and formation rates. Following administration of aspirin, there was
Henneman PH, Maurice PF, Avioli LV, et al. Aspirin Induced Suppression of Paget's Disease of Bone.. Ann Intern Med. 1963;58:720–721. doi: https://doi.org/10.7326/0003-4819-58-4-720_3
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Published: Ann Intern Med. 1963;58(4):720-721.
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