This content is PDF only. Please click on the PDF icon to access.
The bleeding disorders designated as coagulopathies can be differentiated without difficulty from other hemorrhagic diatheses. Petechiae, for instance, are never encountered in "pure" coagulopathies; cerebral and genital hemorrhages are rare.
The clotting defect is very selective in hereditary coagulopathies, only one clotting factor usually being deficient. There are only a few exceptions to this rule (simultaneous deficiency of Factors V and VIII, of Factor VIII and a capillary factor, etc.). Complete lack of one factor produces a severe hemorrhagic diathesis (lack of Hageman Factor excepted); however, concentrations of a few per cents of normal of the respective factor change the
Koller F. American College of Physicians Honorary Fellowship Lecture: Clinical and Genetic Aspects of Coagulopathies.. Ann Intern Med. 1963;58:730. doi: 10.7326/0003-4819-58-4-730_1
Download citation file:
Published: Ann Intern Med. 1963;58(4):730.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use