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The bleeding disorders designated as coagulopathies can be differentiated without difficulty from other hemorrhagic diatheses. Petechiae, for instance, are never encountered in "pure" coagulopathies; cerebral and genital hemorrhages are rare.
The clotting defect is very selective in hereditary coagulopathies, only one clotting factor usually being deficient. There are only a few exceptions to this rule (simultaneous deficiency of Factors V and VIII, of Factor VIII and a capillary factor, etc.). Complete lack of one factor produces a severe hemorrhagic diathesis (lack of Hageman Factor excepted); however, concentrations of a few per cents of normal of the respective factor change the
Koller F. American College of Physicians Honorary Fellowship Lecture: Clinical and Genetic Aspects of Coagulopathies.. Ann Intern Med. 1963;58:730. doi: https://doi.org/10.7326/0003-4819-58-4-730_1
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Published: Ann Intern Med. 1963;58(4):730.
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